Human Brain Transcriptome

The HBT (Human Brain Transcriptome) project at the Department of Neurobiology Yale University School of Medicine is a public database containing transcriptome data and associated metadata for the developing and adult human brain. In the first stage of this project, we provide genome-wide, exon-level transcriptome data generated using the Affymetrix GeneChip Human Exon 1.0 ST Arrays from over 1,340 tissue samples sampled from both hemispheres of postmortem human brains. Specimens range from embryonic development to adulthood and are representative of both males and females from multiple ethnicities. A total of 16 brain regions were sampled: the cerebellar cortex, mediodorsal nucleus of the thalamus, striatum, amygdala, hippocampus, and 11 areas of the neocortex. Genome-wide genotyping data for 2.5 million markers (Illumina Human Omni 2.5-Quad Bead Chips) is available for all specimens upon request. The HBT project is funded by the National Institute of Health (U01MH081896). Additional data will be incorporated into the database as it becomes available. For more information, please contact us.